In Rireinutire, I've done unit prefixes, milk products, military ranks, noble titles, and some astronomical terms. So totally not random lists of things, right? I've tried to avoid totally regular derivations because those are transparent (or will be once I actually let anybody see the list of (still productive) derivational affixes).
I started with the Swadesh list and the Laadan core vocabulary and Rireinu kinship terms, and then expanded in random directions. No clearly defined goal; I just want more! More! I'm still not satisfied!!!
I shall race you. I shall race you to infinity! (Note to self: do comprehensive set of computer science terms.)